2025, Vol. 7, Issue 3, Part B

Background: Type 2 diabetes mellitus (T2DM) is a common metabolic disorder, leading to cardiovascular disease (CVD), such as ischemic heart disease (IHD). The interaction between T2DM and heart disease is bi-directional and is reflected in mechanisms such as oxidative stress, endothelial dysfunction, and insulin resistance. The objective of this study was to assess the biochemical and cardiac markers among diabetic heart patients in comparison with healthy control group.

Methodology: Case-control study was conducted in 140 subjects (70 diabetic patients with hearts disease and 70 normal individuals), aged 41–76 years, the sample collected from Al-Fayhaa Teaching Hospital, Basrah, Iraq. From each participant, the blood samples were obtained and centrifuged to assay for fasting blood glucose (FBS), HbA1c, insulin & CK-MB Automated systems targeted for analytical procedures were Cobas c111, Cobas E411 and Bio-Rad D-10 for standardized enzymatic and immunoassay methods

Results: Showed FBS, HbA1c and insulin levels of diabetic subjects significantly higher (p<0.001) as compared to non-diabetics suggested poor glycemic control consistent with the results. In addition, the diabetic group had significantly higher cardiac biomarkers CK-MB (p<0.001) suggestive of myocardial stretch/damage.

Conclusions The study concluded underscores the relevant metabolic and cardiac changes in diabetic patients with CVD, suggesting the timely biomarker-based follow-up in order to avoid CVD complications.