Hypoproteinemia and Hypoalbumenaemia as Predictor Factors for Severity of Infection and Mortality in COVID – 19 patients
Author(s): Saif Abdulhadi Salih and Mohammed H Hindi
Abstract: Coronaviruses are significant diseases in both humans and animal’s acute respiratory distress syndrome (ARDS), a life-threatening acute, diffuse, inflammatory form of lung injury, is characterized by pulmonary infiltrates, poor oxygenation, and sharpness of onset in critically sick patients.
Assessment of the correlation between total serum protein and serum albumin with severity of respiratory involvement in hospitalized Coronaviruses patients. A prospective cohort study that involved 100 newly diagnosed Coronaviruses patients (confirmed by positive polymerase chain reaction (PCR) test for coronavirus infection from nasopharyngeal swabs) The patients sent for total serum protein and serum albumin (at day of admission, three days after admission and ten days after admission). The diagnosis and assessment of severity according to the WHO classification of COVID-19. The study was carried out in Al Diwaniyah teaching hospital, it started from October 2021 till the end of March 2022.
Both hypoalbuminemia and hypoproteinemia significantly associated with severity of infection of COVID-19(30.0%)
P<0.001 of moderate cases and (98.0%)
P<0.001 of severe cases of Coronaviruses infection have hypoproteinemia during the 10 days follow up , in severe Coronaviruses cases the magnitude of reduction in serum protein and albumin increased with time, this indicates that possibly with time severe case associated with lower values of both markers, Our study reported that hypoalbuminemia observed at admission ( 34.0%)
P<0.001, and after 3 days of admission (50.0%)
P<0.001, and after 10 days of admission (54.0%)
P<0.001 in moderate cases and in severe cases hypoalbuminemia at admission (80.0%)
P<0.001, after 3 days of admission (86.0%)
P<0.001, and after 10 days of admission (84.0%)
P<0.001 of patients. In conclusion the current thesis validated that the COVID-19 is a picture of ARDS, morbidity and mortality increase with low serum protein and serum albumin.
DOI: 10.22271/27069567.2025.v7.i3b.659Pages: 107-114 | Views: 317 | Downloads: 39Download Full Article: Click Here
How to cite this article:
Saif Abdulhadi Salih, Mohammed H Hindi.
Hypoproteinemia and Hypoalbumenaemia as Predictor Factors for Severity of Infection and Mortality in COVID – 19 patients. Int J Adv Res Med 2025;7(3):107-114. DOI:
10.22271/27069567.2025.v7.i3b.659
