Prospective analysis of serum albumin level as prognostic indicator in acute ischemic stroke
Author(s): Dr. Ravikumar Ughreja
Background and Aim: Effect of albumin is primarily in the early reperfusion phase of acute ischemic stroke where it has an inhibitory effect on thrombosis, stagnation and adhesion of leucocytes in microcirculation. Aim of the study is to understand the association between serum albumin on admission and the functional status at 90 days. It also aims to find the other indicators that influence the outcome after ischemic stroke.
Material and Methods: The study population consisted of total 200 patients who were admitted in the hospital wards with the instance of ischameic stroke within the first 2 hours of onset of symptoms. A detailed history was elicited from the attendees, followed by general examination. Serum albumin was measured using Bromocresol Green. Patients were followed up, and after 120 days following the onset of stroke, were evaluated either in person or over the phone using the Modified Ranking scale to assess their functional status.
Results: Maximum numbers of patients were in severe disability score group. The prevalence of systemic hypertension was present tin 114 patients and absent in 86 patients. The association between GCS and albumin was found to be significant (p value<0.05) using the ANOVA test. The mean albumin in those with GCS>13 was 5.34 mg/dl while those for GCS< 9 was 4.26 mg/dl. There was a negative correlation between serum albumin at admission with the MRS score at 120 days. The higher the serum albumin levels, the lower the MRS score, hence better the outcome at 120 days.
Conclusion: Serum albumin has a significant association with the severity as well as the prognosis of stroke.