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International Journal of Advanced Research in Medicine
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2023, Vol. 5, Issue 1, Part A

The value of CD72 presence on memory B cell (CD19+ CD27+) in children with immune thrombocytopenic purpura (ITP)


Author(s): Hend Gamal Elsadat, Ghada Abdel-Moamen Soliman, Ahmed Abdelbaset Abo-Elezz and Fatma Mahmoud Gheith

Abstract: Background:The hemodynamic profiles of cases with severe sepsis and septic shock vary considerably. Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura, is an autoimmune disorder characterised by excessive production of a variety of auto-antibodies.The aim of this work was toinvestigate the value of CD72 presence on memory B cell (CD19+ CD27+) in children with ITP.
Methods: This prospective clinical research was carried out on 40 children aged less than 15 years old. Children were subdivided in to two equal groups: Group A: newly diagnosed ITP who were admitted to pediatric department, Tanta University hospital. These cases were diagnosed on the basis of clinical presentation, morphological and cytochemical smears of peripheral blood and bone marrow as well as immunophenotyping and group B (control group): apparently healthy children as a control group.
Results: There was significant association between CD72 (%) and both platelet count and platelet autoantibodies for group I. A notable association between CD72 (%) and sex for group I with P=0.037. ROC curve of CD72 (%) presence on memory B cells to diagnose ITP cases group I; excellent AUC was found (AUC = 0.965, p<0.001). At cut-off value >3.5%, sensitivity 70%, specificity 90%, PPV 90% and NPV 76.9%. Figure 1.
Conclusions: There was high significant rise in the presence of CD72% in children with ITP. A notable association between memory B cell (CD19, CD27) % and CD72 (%) in children with ITP. CD72 (%) presence on memory B cells can diagnose ITP.


DOI: 10.22271/27069567.2023.v5.i1a.431

Pages: 14-19 | Views: 389 | Downloads: 171

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International Journal of Advanced Research in Medicine
How to cite this article:
Hend Gamal Elsadat, Ghada Abdel-Moamen Soliman, Ahmed Abdelbaset Abo-Elezz, Fatma Mahmoud Gheith. The value of CD72 presence on memory B cell (CD19+ CD27+) in children with immune thrombocytopenic purpura (ITP). Int J Adv Res Med 2023;5(1):14-19. DOI: 10.22271/27069567.2023.v5.i1a.431
International Journal of Advanced Research in Medicine
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