Manuscript Writing Service
International Journal of Advanced Research in Medicine
Printed Journal   |   Refereed Journal   |   Peer Reviewed Journal

International Journal of Advanced Research in Medicine

2022, Vol. 4, Issue 2, Part A

Cinnamon's effect on apoptosis, inflammation and trpm2 channels in methotrexate induced renal damage


Author(s): Ali Gürel, Ahmet Türk, Hasan Aydın, Fatih Genç and Alper Yalçın

Abstract:
Introduction: In this study, it was aimed to investigate the potential protective effects of cinnamon (CIN) against methotrexate (MTX) induced kidney damage.
Materials and Methods: Spraque dawley male rats were divided into five groups (n = 7) as: control group received no treatment; oil group was administered 1ml/kg olive oil (OO) by oral gavage during the experiment; MTX group was given OO by gavage once a day for 14 days and a single dose of 20 mg/kg MTX was injected intraperitoneally on the third day; CIN group was given 100 mg/kg CO (CIN bark oil) by oral gavage throughout the experiment; MTX+CO group received 100 mg/kg CO throughout the experiment and injected with a single dose of 20mg/kg MTX IP on the third day. In the end of the experiment, the animals were decapitated and the kidneys were removed.
Results: MTX administration caused glomerular atrophy, tubular enlargement and increased TRPM2 immunoreactivity on kidney tissue and CIN reversed these changes significantly.
Conclusion: In this study, it was determined that MTX caused histological damage on kidney tissue and CIN reduced this damage.


DOI: 10.22271/27069567.2022.v4.i2a.387

Pages: 06-10 | Views: 76 | Downloads: 41

Download Full Article: Click Here
How to cite this article:
Ali Gürel, Ahmet Türk, Hasan Aydın, Fatih Genç, Alper Yalçın. Cinnamon's effect on apoptosis, inflammation and trpm2 channels in methotrexate induced renal damage. Int J Adv Res Med 2022;4(2):06-10. DOI: 10.22271/27069567.2022.v4.i2a.387
International Journal of Advanced Research in Medicine