International Journal of Advanced Research in Medicine
2022, Vol. 4, Issue 2, Part A
Cinnamon's effect on apoptosis, inflammation and trpm2 channels in methotrexate induced renal damage
Author(s): Ali Gürel, Ahmet Türk, Hasan Aydın, Fatih Genç and Alper Yalçın
Introduction: In this study, it was aimed to investigate the potential protective effects of cinnamon (CIN) against methotrexate (MTX) induced kidney damage.
Materials and Methods: Spraque dawley male rats were divided into five groups (n = 7) as: control group received no treatment; oil group was administered 1ml/kg olive oil (OO) by oral gavage during the experiment; MTX group was given OO by gavage once a day for 14 days and a single dose of 20 mg/kg MTX was injected intraperitoneally on the third day; CIN group was given 100 mg/kg CO (CIN bark oil) by oral gavage throughout the experiment; MTX+CO group received 100 mg/kg CO throughout the experiment and injected with a single dose of 20mg/kg MTX IP on the third day. In the end of the experiment, the animals were decapitated and the kidneys were removed.
Results: MTX administration caused glomerular atrophy, tubular enlargement and increased TRPM2 immunoreactivity on kidney tissue and CIN reversed these changes significantly.
Conclusion: In this study, it was determined that MTX caused histological damage on kidney tissue and CIN reduced this damage.
Ali Gürel, Ahmet Türk, Hasan Aydın, Fatih Genç, Alper Yalçın. Cinnamon's effect on apoptosis, inflammation and trpm2 channels in methotrexate induced renal damage. Int J Adv Res Med 2022;4(2):06-10. DOI: 10.22271/27069567.2022.v4.i2a.387