Pattern in Minimum Inhibitory Concentration of Vancomycin and Tigecycline on Clinical Isolates of Enterococcus Species Isolated from Clinical Samples at our Tertiary Care Hospital
Author(s): Maureen Edwards
Abstract: Background: Genus
Enterococcus have emerged as nosocomial pathogens. Urinary tract infections followed by intra-abdominal abscesses, Wounds, usually intra-abdominal or pelvic, are the next most common sites. Bacteremia is the third most common infection caused by
Enterococci. Enterococcal meningitis is rare and is seen primarily in neonates and inpatients who have undergone complicated neurosurgical procedures
[4]. There is an increasing role of
Enterococci in nosocomial infections in the recent years mostly because of their intrinsic resistance to many clinically useful antibacterial drugs. One of the leading cause of nosocomial infection is Vancomycin-resistant Enterococci (VRE). For good therapy an effective, accurate and early detection of VRE along with Minimum Inhibitory Concentrations (MIC) is necessary. Tigecycline has a broad spectrum of activity against
enterococci (vancomycin-susceptible). Haemolysin is a cytolytic protein and the producing strains of
Enterococci have been shown to be associated within creased severity of infection [9]. In order to know the current scenario of minimum inhibitory concentration of Vancomycin and Tigecycline and the production of Haemolysin by some strains of
Enterococci, the present study has been done.
Methods: This study was performed on Clinical isolates of Enterococcus which were received from tertiary care hospitals and processed at Department of Microbiology, Kasturba Medical College, Mangalore and Microbiology diagnostic laboratory (KMC hospital, Ambedkar circle), Mangalore. The study was done for a period of 6 months from Nov 2017-May2018. Convenient non-random sampling method was followed to collect clinical isolates. All isolates of Enterococcus from various clinical specimens like pus, deep tissue, urine, blood and body fluids were included in the study. Result: Out of 100 Enterococcus isolates collected, majority were of E. faecium. Among all the isolates, 5% were resistant to vancomycin, but 100% sensitivity to tigecycline. Hemolysin produced by 46% of the total isolates. It has shown its association of the Enterococcus species to various antibiotics and their resistant pattern.
DOI: 10.22271/27069567.2021.v3.i1f.160Pages: 331-335 | Views: 1080 | Downloads: 559Download Full Article: Click HereHow to cite this article:
Maureen Edwards.
Pattern in Minimum Inhibitory Concentration of Vancomycin and Tigecycline on Clinical Isolates of Enterococcus Species Isolated from Clinical Samples at our Tertiary Care Hospital. Int J Adv Res Med 2021;3(1):331-335. DOI:
10.22271/27069567.2021.v3.i1f.160
