International Journal of Advanced Research in Medicine
2021, Vol. 3, Issue 1, Part E
Assess the role of serum adenosine deaminase as a glycaemic status indicator, among patients with type 2 Diabetes in a tertiary care centre, Telangana state
Author(s): Dr. R Penta Chary and Dr. G Sukumar
Abstract:Introduction: Most common and many people around world and in India are vulnerable to diabetes mellitus and in this diabetes the commonest is type 2 diabetes mellitus and it is a metabolic disorder which is characterized by high blood glucose levels. Metabolic disorders mainly relay upon enzymes and their functions or dysfunctions, one among that enzyme is Adenosine Deaminase (ADA). The ADA is an enzyme which catalyses the irreversible deamination of adenosine to inosine. Adenosine is known to exert potent metabolic effects acting through its receptors. Increased levels of serum ADA has been shown in individuals with type 2 diabetes mellitus. This study aims to understand the relationship between serum ADA and blood glucose levels.
Methodology: Hospital based observational study, which was conducted at RVM Hospital, Siddipet district, Telangana state. It involved 50 cases of uncomplicated type 2 diabetes mellitus and 50 controls. Study was conducted after obtaining an informed written consent from cases and controls.
Results: It is observed that there is gross elevation of serum ADA in diabetic subjects as compared to controls and moreover a positive correlation was found between serum ADA and blood glucose levels.
Conclusion: This study shows ADA level is significantly related to the glycaemic status in type 2 diabetes mellitus. This study highlights the importance of this metabolite and the need for further studies.
Dr. R Penta Chary, Dr. G Sukumar. Assess the role of serum adenosine deaminase as a glycaemic status indicator, among patients with type 2 Diabetes in a tertiary care centre, Telangana state. Int J Adv Res Med 2021;3(1):278-281. DOI: 10.22271/27069567.2021.v3.i1e.152