2021, Vol. 3, Issue 1, Part D

Background: High blood pressure has been associated with elevated atherogenic blood lipid fractions. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanisms where by hypertension is associated with increased risk of coronary heart disease.

Methods: The serum lipid profiles of 100 hypertensive patients was studied and compared with those of healthy controls. The serum lipid profiles (TC, TGL.HDL, VLDL, LDL, TC/ HDL, LDL/HDL ratios) were studied with respect to various clinical profiles like age, sex, type, incidence etc. Study group consisted of patients with hypertension as identified by history, clinical examination, and other relevant examinations.

Results: Serum TC, TGL, VLDL, LDL, TC/ HDL, LDL/HDL were significantly elevated in hypertensive group as compared to healthy controls. Serum HDL was low in patients with hypertension as was compared with controls, which was statistically significant. The LDL was raised in obese compared to non-obese patients, which is statistically very significant. TC/ HDL and LDL /HDL were also raised in obese patients which is statistically significant. TC is raised in CVA group, which is statistically highly significant. LDL is raised in CVA group, which is statistically very significant. TC/ HDL and LDL/HDL are raised in CVA group compared to non-CVA group, which is statistically very significant. TC is raised in IHD group, which is statistically significant. LDL is raised in IHD group, which is statistically very significant. LDL/HDL is raised in men, which is statically significant.

Conclusion: There is significant alteration of lipid profile in hypertensive patients as compared to controls. Total cholesterol, LDL cholesterol, triglycerides, VLDL, TC/HDL and LDL/HDL ratios are significantly elevated in patients with hypertension. HDL is significantly reduced in hypertensive patients. Hyperlipidemia is seen in majority of cases of hypertension with Type IIa pattern being the most frequent. Mean TC, LDL, TC/HDL, LDL/HDL were higher in obese. Mean TC, LDL, TC/HDL and LDL/HDL ratios are raised in CVA group. Mean TC and LDL are raised in IHD group.