International Journal of Advanced Research in Medicine
2020, Vol. 2, Special Issue 2, Part A
A retrospective study of determination of lipid profile level and CRP level in offspring of DM patients
Author(s): Dr. Sunil Kumar Gulati
Abstract:Background: Type 2 diabetes mellitus is associated with a number of other metabolic disorders including elevated triglycerides (TGs), low high‐density lipoprotein cholesterol (HDL‐C) and central obesity. The present study determined lipid profile and CRP level in offspring of diabetes mellitus patients.
Materials and Methods: 50 offspring of T2DM patients (Group I) and 50 healthy controls (Group II) were recruited. Assessment of plasma glucose level, serum hs-CRP, serum cholesterol serum TGs, and high-density lipoprotein (HDL) levels was done.
Results: The mean random blood glucose level in group I was 94.2 mg/dl and in group II was 93.4 mg/dl, hs- CRP was 2.6 mg/dl in group I and 1.4 mg/dl in group II, TG (mg%) was 169.2 and 126.3 in group I and group II, TC (mg%) was 176.4 and 146.2 in group I and group II, HDL (mg%) was 38.2 and 54.3 in group I and group II, LDL (mg%) was 106.2 and 74.4 in group I and group II and VLDL was 34.5 mg% in group I and 26.1 mg% in group II. The difference was significant (P<0.05). There was positive correlation of TG (r-0.26, P<0.05), TC (r-0.41, P<0.05), LDL (r-0.42, P<0.05) and VLDL (r- 0.29, P<0.05) and negative correlation of HDL (r- -0.26, P<0.05) with hs-CRP.
Conclusion: There was alteration of lipid profile and increased level of high-sensitivity C-reactive protein in offsprings of type II diabetes parents.