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International Journal of Advanced Research in Medicine
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International Journal of Advanced Research in Medicine

2020, Vol. 2, Issue 2, Part D

Whey preparation improved altered expression of stress marker and biochemical parameter by etoposide induced mucositis in experimental rats


Author(s): Sudarshan Reddy C, Sham Kishor, NG Herekar and Venkappa Manthoor

Abstract: Background: Anticancer drugs are more commonly used for treatment of solid tumour such breast, kidney, prostate cancer etc. These drugs are produce uncontrolled adverse event like mucosities, diarrhoea very often and there by alteration in the oxidative stress markers and biochemical enzymes leads to cell apoptosis. This study is investigating the effect of whey protein (WP) on chemotherapy induced mucosities. Single dose of etoposide was administered (i.v) to induce the mucosities, WP (oral) along with etoposide was administered after 72 hours rats were sacrificed to perform, biochemical analysis like Na,K-ATPase, sucarse, GSH.
Results: Compared to etoposide treatment, administration of whey protein was reduced levels Enzymes such as sucrase and Na,K-ATPase was reverted (p<0.001, p<0.01) back to more than normal levels. GSH was reduced after post and pre-post treatment of WP along with etoposide. Improvement in the villous structure was observed after treatment of WP. In contrast to normal control and WP control, there was no changes was observed in all the above-mentioned parameters.
Conclusion: The present study provides evidence that stress markers and biochemical enzyme duodenum tissue are closely related to amelioration of chemotherapy induced mucosities with the treatment of whey protein.


DOI: 10.22271/27069567.2020.v2.i2d.84

Pages: 257-261 | Views: 15 | Downloads: 7

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How to cite this article:
Sudarshan Reddy C, Sham Kishor, NG Herekar, Venkappa Manthoor. Whey preparation improved altered expression of stress marker and biochemical parameter by etoposide induced mucositis in experimental rats. Int J Adv Res Med 2020;2(2):257-261. DOI: 10.22271/27069567.2020.v2.i2d.84
International Journal of Advanced Research in Medicine