2020, Vol. 2, Issue 1, Part A

Introduction: Dyslipidemias are a growing problem in world health, but patients often go undiagnosed and untreated. The researchers in this study wanted to see how much of a difference taking 20 mg of Atorvastatin daily with 5 mg of biotin daily made in terms of the percentage change from baseline in lipid parameters at weeks compared to the control group.

Methods: Following the acquisition of written informed consent, 50 patients with secondary dyslipidemia and ages 45 to 60 were included. This study was conducted at the Department of Pharmacology, Shree Lakshmi Narayana Institute of Medical Sciences Pudduchery, India between March 2019 to February 2020. They were randomly assigned to one of two groups after completing baseline laboratory examinations and lipid profiles. Those who served as controls. Received Atorvastatin 20 mg alone and the study group received Biotin 5mg combined with Atorvastatin 20 mg for 6 weeks. Twelve weeks of follow-up were conducted with both groups.

Results: At 6 weeks, total cholesterol, LDL cholesterol, triglycerides, and very low density lipoprotein (VLDL) were all lower with combination therapy than with monotherapy. There was no statistically significant difference between the groups when Biotin was added, however HDL levels rose even more. Optimal levels of total cholesterol to HDL were achieved in the combination group, where the ratio reached 3.54. Combined treatment also reduced adverse events.

Conclusion: When compared to Atorvastatin alone, the efficacy of a combination therapy involving 5 mg of biotin and 20 mg of atorvastatin in lowering total cholesterol, LDL cholesterol, and triglycerides is significantly higher. When used as an adjuvant hypolipidemic medication in cases of secondary dyslipidemia, biotin is both safe and well-tolerated.