An evaluation of hepatic parameters in congestive heart failure and its correlation with Aetiology and duration: a Prospective study
Author(s): Dr. Shailendra Singh Rajpoot
Abstract:Aims: The aim of the study to find out the prevalence of liver function abnormalities in heart failure patients, pattern of elevation of liver enzymes and correlation of liver function tests with etiology, duration and of heart failure.
Material and methods: This is a prospective study was conducted in the Department of General Medicine, Metro Hospital and Cancer Research Centre, Jabalpur, MP, India from October 2018 to January 2020. The hepatic biochemical parameters like serum bilirubin (direct, indirect and total), serum AST and ALT, Serum alkaline phosphatase, Serum proteins and Prothrombin time were estimated.
Results: In present study mean age of patient was 57.68±11.78 years. Maximum number of patients was from 50 to 75 years of age that is 45 (56.25%). As per NYSA classification maximum number of cases were class II (46.25%) followed by class III (26.25%). Percentage of patients with class I were 18.75% and class IV were 8.75%. Maximum number of patients has disease from to 4-year duration that is 66.25%. Regarding clinical presentation of patient’s jaundice was present in 27.5%, hepatomegaly which was most commonly present that was 47.5%, ascites was present in 28.75% and congested hepatomegaly in USG (41.25%). Regarding hepatic biochemical parameters there is significant variation in serum bilirubin (mg/dl) parameter as per progress in class of heart failure (p=0.001). Serum bilirubin was 3.88±1.57 mg/dl in class IV and least in class I that is 1.132±0.28 mg/dl. Serum AST was highest in class IV 161.14±25.85 IU and least in class I that is 35.68±11.87 IU (p=0.001). Serum ALT was highest in class IV 188.98±35.85 IU and least in class I that is 35.11±10.56 (p=0.001).
Conclusion: The heart failure was common in fifth and sixth decade of life and there was male predominance.
Dr. Shailendra Singh Rajpoot. An evaluation of hepatic parameters in congestive heart failure and its correlation with Aetiology and duration: a Prospective study. Int J Adv Res Med 2020;2(1):71-74. DOI: 10.22271/27069567.2020.v2.i1a.128