Role of methylene blue in treatment of oral lichen planus
Author(s): Dr. Sanjay Mishra MD and Dr. Shaikh Ifterkhar
Introduction: Methylene blue, widely used as a histologic dye, has potential photochemical and photo biological properties favoring its use as a photosensitizer in photodynamic therapy (PDT) of varied diseases. This study was designed to assess the efficacy of MB mediated PDT in treatment of Oral Lichen Planus.
Materials and Methods: A sample selection of 37 patients was done based upon a predefined set of inclusion and exclusion determinants from the Outpatient Department Radiotherapy, IMS and SUM Hospital. This study encompassed anon-randomized, non-comparative prospective split mouth study protocol. Pre-treatment assessment of clinical presentation and symptoms was done using REU and VAS score respectively. The subjects were treated with a single session of MB-PDT and followed up after 2 weeks, 1 month and 3 months from baseline. The post treatment REU and VAS recorded at each visit for the test and control site separately.
Findings: For the final sample of 35 recruits, repeated measure ANOVA was used for analysis of REU and VAS score among various visits in test group. With respect to REU scores, statistically significant results were obtained for baseline with 3 months follow up, for 2 weeks with 3 months follow up and for 4 weeks with 3 months follow up. The VAS score was statistically significant amongst all comparisons.
Conclusion: MB is photo chemically and photo biologically a dynamic molecule which can be effectively harnessed to target various premalignant and malignant pathologies to prevent its progression.