2025, Vol. 7, Issue 3, Part C

Author(s): Rina Puspita, Arief Santoso and Siti Nurhaliza

Abstract: Diabetes mellitus (DM) has become a global health crisis, with its prevalence steadily increasing and posing significant challenges to healthcare systems worldwide. Conventional treatments, including insulin therapy and oral hypoglycemic agents, are often accompanied by adverse effects and a decline in efficacy over time. As a result, there is growing interest in complementary and alternative therapies, particularly those derived from medicinal plants. Pomegranate L. (pomegranate), a fruit known for its rich polyphenolic content, has demonstrated promising therapeutic potential for managing DM. This systematic review critically evaluates preclinical and clinical studies investigating the effects of Pomegranate extracts on glycemic control in diabetes. The findings suggest that pomegranate extracts, including juice, peel, and seed, significantly reduce fasting blood glucose levels, improve HbA1c levels, enhance insulin sensitivity, and reduce oxidative stress markers. The bioactive compounds in pomegranate, such as punicalagins, ellagic acid, and anthocyanins, contribute to these effects by inhibiting carbohydrate-hydrolyzing enzymes, improving insulin function, and providing antioxidant protection. Despite promising results, the variability in study designs, dosages, and treatment durations calls for further research to establish standardized protocols and confirm the long-term safety and efficacy of Pomegranate as an adjunct therapy for diabetes management. This review highlights the potential of pomegranate as a natural, cost-effective strategy for improving glycemic control in diabetic patients, with implications for clinical practice and future research.

DOI: 10.22271/27069567.2025.v7.i3c.668

Pages: 184-189 | Views: 709 | Downloads: 431

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