A cross-sectional study for lipid profile as an indicator of severity in cirrhosis of liver
Author(s): Dr. KS Manjesh and Dr. Chandregowda
Abstract: Background: Various scoring systems are available to assess the severity of cirrhosis, that is, the Child-Pugh score and Model for End-Stage Liver Disease (MELD) score. Since the liver is the major site for converting excess carbohydrates into various lipids, the deranged lipid profile can act as a prognostic biomarker of cirrhosis. We assessed the lipid profile abnormalities among patients with cirrhosis of the liver and correlated them with the severity of cirrhosis.
Materials and Methods: This study is an analytical cross-sectional examination of lipid profiles as a determinant of severity in liver cirrhosis among patients hospitalized in the medical ward of a tertiary care teaching hospital in Mandya. Subsequent to a thorough investigation and verification of cirrhosis, a fasting serum lipid profile was assessed in all qualifying individuals diagnosed with cirrhosis. Total serum cholesterol, triglycerides (TGL), and high-density lipoprotein (HDL) were assessed using direct methods, while serum low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) were computed utilizing the Friedwald formula.
Results: A total of 70 patients were studied. Of them, 64(91.4%) were male. Of them, alcohol (59, 85.0%), hepatitis B (6, 8.5%), and nonalcoholic steatohepatitis (NASH) (4, 5.7%) were the most common cause of cirrhosis. A clear dose-response association (decreasing trend) is observed in lipid levels corresponding to escalating severity according to the Child-Pugh score. Moreover, cholesterol, LDL, and HDL levels were markedly reduced in patients with ascites or spontaneous bacterial peritonitis compared to their respective cohorts.
Conclusion: This study found that when the severity of cirrhosis develops, there is a significant decrease in the levels of lipid profile indices such as blood total cholesterol, LDL, VLDL, TGL, and HDL in patients. A more accurate evaluation of the prognosis of patients in light of morbidity and mortality might result from further development of the scoring system in conjunction with an already-existing scoring system.
DOI: 10.22271/27069567.2024.v6.i3b.579Pages: 118-121 | Views: 59 | Downloads: 16Download Full Article: Click Here
How to cite this article:
Dr. KS Manjesh, Dr. Chandregowda.
A cross-sectional study for lipid profile as an indicator of severity in cirrhosis of liver. Int J Adv Res Med 2024;6(3):118-121. DOI:
10.22271/27069567.2024.v6.i3b.579