Serum adropin as a biomarker of diabetic nephropathy in type 2 diabetic patients
Author(s): Ahmed Alsayed Huntsh, Shireen Ali Elhoseny, Rasha Adel Elkholy and Tamer AbdElhamid Elbedewy
Abstract: Background: Adropin (AD) regulates the metabolic balance of the heart, blood vessels, kidneys, along with skeletal muscles in relation to nutritional condition. Our research was designed to assess if serum AD levels could be implemented as a biomarker for diabetic nephropathy among cases developing T2DM.
Methods: The case-control study included 60 adult patients above 18 years old of both sexes who develop T2DM in addition to 20 subjects in good health as a control group. Our team categorized all subjects equally into four groups. Group (1): involved twenty nondiabetic controls. Group (2) involved twenty adult cases developing T2DM and normal albuminuria [urinary albumin creatinine ratio (UACR) below 30 mggm)]. Group (3) included 20 adult cases developing T2DM and microalbuminuria (UACR below 30 mggm). Group (4) included 20 adult cases developing T2DM and macroalbuminuria (UACR over 300 mggm).
Results: AD can significantly predict diabetic nephropathy (AUC = 0.907) at cut-off 225 with 90% sensitivity, and 85% specificity. A significant negative association was noted among serum AD as well as age, duration of disease, FBG, 2HPPG, glycated hemoglobin, UACR, cholesterol, triglycerides, low-density lipoprotein, creatinine, blood urea nitrogen, uric acid. A significant positive relationship was also noted among AD and high-density lipoprotein, albumin, and hemoglobin. No association was found between AD and aspartate aminotransferase, alanine transaminase, total leucocyte count, platelets.
Conclusion: Serum AD level was significantly reduced among cases developing T2DM with microalbuminuria. Serum AD may promise alternative serum marker in terms of predicting DKD cases from diabetics.
DOI: 10.22271/27069567.2024.v6.i3a.568Pages: 36-43 | Views: 150 | Downloads: 60Download Full Article: Click Here
How to cite this article:
Ahmed Alsayed Huntsh, Shireen Ali Elhoseny, Rasha Adel Elkholy, Tamer AbdElhamid Elbedewy.
Serum adropin as a biomarker of diabetic nephropathy in type 2 diabetic patients. Int J Adv Res Med 2024;6(3):36-43. DOI:
10.22271/27069567.2024.v6.i3a.568