2023, Vol. 5, Issue 4, Part A

Background: Several endocrine system abnormalities are linked to liver cirrhosis. The objective of this study was to evaluate the prognostic significance of serum cortisol level and serum prolactin level and complications of liver cirrhosis and its severity and follow up mortality on 90 days.

Methods: This prospective cohort research was done on10 control and 50 patients and, aged more than 18 years old, with liver cirrhosis and/or its complications. Patients were categorized into 3 groups: Group I (25 patients): Compensated cirrhosis. Group II (25 patients): Decompensated cirrhosis. Group III (10 standards): Normal healthy participants.

Results: The sensitivity and specificity for mortality were 82% and 74% for cortisol AM at cut off 101, were 88% and 84% for cortisol PM at cut off 97 ng/dl. Specificity and sensitivity for mortality depended on prolactin level cut off 20 were 68%, 72% respectively. In univariate all items except spontaneous bacterial peritonitis were significant and multivariate all items except urea, creatinine, encephalopathy and hepatorenal syndrome were significant.

Conclusions: Higher prolactin and lower cortisol levels could therefore be considered as diagnostic factor of liver cirrhosis Child and its complications. Therefore, cortisol and prolactin can be regarded as a novel prognostic factors of liver cirrhosis and prediction of mortality and morbidity.