2021, Vol. 3, Issue 2, Part I

Aim: To determine the correlation between diastolic dysfunction (DD) and HBA1C levels in type II diabetes mellitus patients.

Materials and Method: The present prospective study was conducted in the department of General Medicine, OPD, Medical wards, Chattrapati Shivaji Subharti Hospital, Meerut among 200 patients of Type 2 diabetes mellitus. Diabetes was diagnosed according to American diabetes association guidelines. Reduction in peak velocity of early mitral flow (E) increase over peak velocity of late mitral flow (A) with E/A ratio of <1 and increase in left atrial (LA) size with preserved ejection fraction were considered as the evidence of left ventricular diastolic dysfunction. Reduction in E velocity increase over A velocity with E/A ratio of <1 and increase in left atrial (LA) size with preserved ejection fraction (EF) was considered as the evidence of left ventricular diastolic dysfunction. Data was collected and subjected to statistical analysis.

Results: 66.5% subjects had HbA1c level ≥8.1 and 33.5% subjects had <8.1. Left atrium volume index and E/e′ were significantly higher in subjects with HbA1c≥8.1 as compared to subjects with HbA1c<8.1. Isovolumetric relaxation time was significantly less in subjects with HbA1c≥8.1 as compared to subjects with HbA1c<8.1. Among the subjects with <8.1 HbA1c level, incidence of LVDD was present in 37.31% subjects whereas among the subjects with HbA1c level ≥8.1, incidence of LVDD was present in 61.65% subjects.

Conclusion: HbA1C emerges as an important indicator of diastolic dysfunction in early onset diabetes population in the study.