2021, Vol. 3, Issue 2, Part H

Methods: 103 cases of OP poisoning admitted to the rajah Muthiah medical college Hospital between November 2019 – October 2021 were studied. Patients above 18 years of age were included and those patients with mixed poisoning, Alcohol consumption, and diabetes were excluded. Detailed history and clinical examination were done according to the proforma with special reference to the need for ventilatory support, admission RBS and pseudocholinesterase levels.

Results: Of the 103 patients, males were 57%, females 43%, the majority were between 18-25 years with farmers (55%) as the main group and suicidal ingestion (93%) as the main cause. Methyl parathion was the commonest compound (15%) consumed but most of the time the compound was unknown (33%). The commonest symptoms were vomiting (94%) and salivation (94%). Respiratory failure was the commonest complication (30%). Hyperglycemia occurred in 39% of patients with 73% developing complications and 50% requiring a ventilator. Pseudocholinesterase was less than 4000U/L in 19% of patients, with complications occurring in 100% and 79% requiring ventilator support. Mortality was 35% in patients with hyperglycemia (p<0.05 S) and 79% in patients with pseudocholinesterase <4000U/L (p<0.001HS).

Conclusion: Admission Random Blood sugar >200mg/ dl and Pseudocholinesterase <4000 U/L are reliable parameters to predict mortality and ventilator requirement in organophosphorus compound poisoning. By Chi-Square Test, drop-in Pseudocholinesterase level and increase in blood sugar level were associated with ventilator requirements, mortality, and complications, and was found to be significant.