Assessment of thyroid dysfunction in beta thalassemia patientsAuthor(s):
Dr. Nagendra Singh ChauhanAbstract:
Background: Thalassemia is the most common inherited monogenic disorder in the world.
The present study was conducted to assess thyroid dysfunction in thalassemia patients.
Materials & Methods: 84 children with beta thalassemia major of both genders were assessed for serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and Serum ferritin levels were obtained. TSH and T4 concentration were analyzed by ELISA.
Results: There were 64 euthyroid and 20 hypothyroid patients. 40 male and 24 females euthyroid patients and 12 males and 8 hypothyroid patients. The difference was significant (P< 0.05). The amount of blood transfused was 230.4 ml/kg and 272 ml/kg, serum ferritin (ng/ml) level was 1972.5 and 28.16, serum TSH µIU/ml was 3.05 and 7.14, serum free T4 (pmol/l) was 12.7 and 10.6 and serum free T3 (pmol/l) level was 6.14 and 4.52 in euthyroid and hypothyroid patients. The difference was significant (P< 0.05).
Conclusion: Severity of thyroid dysfunction in thalassemia patients was variable.DOI: 10.22271/27069567.2021.v3.i1e.150Pages: 272-274 | Views: 18 | Downloads: 9Download Full Article: Click Here
How to cite this article:
Dr. Nagendra Singh Chauhan. Assessment of thyroid dysfunction in beta thalassemia patients
. Int J Adv Res Med 2021;3(1):272-274. DOI: 10.22271/27069567.2021.v3.i1e.150