International Journal of Advanced Research in Medicine
2021, Vol. 3, Issue 1, Part A
Serum levels of nitric oxide among diabetic patients and its correlation with lipid profile and oxidative stress
Author(s): Dr. Ramakant Rawat and Dr. Amit Varshney
Abstract:Background: Diabetes mellitus is a disease with a rapidly increasing prevalence. The present study was conducted to assess the serum levels of nitric oxide (NO) among diabetic patients and its correlation with lipid profile as well as oxidative stress.
Materials and Methods: 150 cases of type II diabetes were divided into three groups: Group I was type 2 diabetics with dyslipidemia and hyperuricaemia, group II was type 2 diabetics with dyslipidemia and normouricaemia and group III was type 2 diabetics with normolipidemia and normouricaemia. Patient was subjected to estimation of lipid profile. Nitric oxide level was determined.
Results: Group I had 35 males and 15 females, group II had 20 males and 30 females and group III had 25 males and 25 females. The mean nitric oxide level (µmol/L) in patients with increased triglyceride level in group I was 46.2, 72.0 in group II and 74.2 in group III and in patients with increased cholesterol level was 34.2 in group I, 54.6 in group II and 72.4 in group III, in patients with increased HDL level was 45.2 in group I, 58.4 in group II and 76.0 in group III and in patients with increased LDL level was 42.0 in group I, 60.4 in group II and 72.1 in group III. There was poor correlation of antioxidants with NO in all groups.
Conclusion: Oxidative stress parameters had poor correlation with NO level in all the groups.
Dr. Ramakant Rawat, Dr. Amit Varshney. Serum levels of nitric oxide among diabetic patients and its correlation with lipid profile and oxidative stress. Int J Adv Res Med 2021;3(1):33-35. DOI: 10.22271/27069567.2021.v3.i1a.100