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International Journal of Advanced Research in Medicine
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International Journal of Advanced Research in Medicine

2020, Vol. 2, Issue 2, Part C

To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of proteinuria


Author(s): Nishanam Gururaj and Pillalamarri Purnima

Abstract: Background: Proteinuria is an independent risk factor for diabetic nephropathy and a predictor of end-stage renal disease. Measurement of protein excretion in a 24hr urine collection is the gold standard for the quantitative evaluation of proteinuria in diabetes. However, this is cumbersome, subjective to collection errors and required good compliance.
Aims: To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of Proteinuria.
Materials and methods: We compared 24 hr urine protein estimation with urine spot protein creatinine ratio in type 2 diabetes mellitus patients with proteinuria.
Results: In our study of 73 patients with type 2 diabetes mellitus and proteinuria, it was found that A maximum number of patients were noted in the age group 41-50 years. Males were more than females in the ratio of 2.04:1. The majority of patients had a duration of diabetes between 5 -10 yrs (52.05%). The mean duration of diabetes was 9.24+/- 6.1 yrs. Twenty-five patients (34.25%) had nephrotic range proteinuria. There was a good correlation between urine PCR and 24 hr urine protein at different levels of GFR. Maximum correlation between urine PCR and 24 hr urine protein was seen in the GFR >60 group. There was a good correlation between urine PCR and 24 hr urine protein at different ranges of proteinuria. A maximum correlation between urine PCR and 24 hr urine was seen in the proteinuria group <300. There was a good correlation between urine PCR and serum creatinine. No statistically significant correlation was found between HBA1C levels and degree of proteinuria.
Conclusion: Urine protein creatinine ratio can be used as a faster diagnostic substitute for 24 hr urine protein estimation in the screening and evaluation of diabetic nephropathy.


DOI: 10.22271/27069567.2020.v2.i2c.65

Pages: 173-179 | Views: 109 | Downloads: 33

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How to cite this article:
Nishanam Gururaj, Pillalamarri Purnima. To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of proteinuria. Int J Adv Res Med 2020;2(2):173-179. DOI: 10.22271/27069567.2020.v2.i2c.65
International Journal of Advanced Research in Medicine