Serum Adiponectin in women with polycystic ovary syndrome of different body mass index Author(s):
Rasha Hatem Abbas, Sarab Adnan Waseen and Bushra Abdullah NajumAbstract: Background:
Polycystic ovary syndrome is an extremely common disorder in women of the reproductive age that is associated with a disturbance of reproductive, endocrine, and metabolic functions. The pathophysiology of PCOS appears to be multifactorial and polygenic. Adiponectin seems to play an important role in the pathogenesis of PCOS, especially in obese women.
Objectives: To (1) measure serum adiponectin levels in women with PCOS of different body mass index; and (2) assess possible relation between adiponectin level and the hormonal changes of the disease.
Setting: Baghdad Teaching Hospital. Duration of study one year from 2018 to 2019.
Methods: 80 women were included in this study, 40 women were suffering from PCOS (study group), and the remainder 40 were healthy women served as a control group. BMI is calculated, then each group subdivided into 2 groups: overweight with BMI≥25Kg/m2 and the normal weight with BMI<25Kg/m2. Hormonal profile: [LH, FSH, LH/FSH ratio, testosterone, TSH, T4, and prolactin] were measured. Pelvic U/S scan done to confirm the diagnosis. Serum adiponectin level was measured in both groups by Enzyme-linked immunosorbent assay [ELISA test].
Results: Mean serum adiponectin level was significantly lower in PCOS women with BMI<25Kg/m² compared to control women with BMI<25Kg/m² (17.26±5.10, 26.26±7.36 respectively with P-value =0.0001[<0.05]), while the mean serum adiponectin level in PCOS women with BMI≥25Kg/m² was lower than control women with BMI≥25Kg/m² (9.77±2.01, 10.08±2.70 respectively with P-value = 0.682) which is statistically not significant.
Conclusion: Adiponectin is significantly low in women suffering from PCOS. DOI: 10.22271/27069567.2020.v2.i2b.55Pages: 105-109 | Views: 454 | Downloads: 193Download Full Article: Click Here
How to cite this article:
Rasha Hatem Abbas, Sarab Adnan Waseen, Bushra Abdullah Najum. Serum Adiponectin in women with polycystic ovary syndrome of different body mass index
. Int J Adv Res Med 2020;2(2):105-109. DOI: 10.22271/27069567.2020.v2.i2b.55