Epidemiological and bacteriological profile of hospital-acquired pneumonia with special reference to Klebsiella pneumoniae and its characterization by Antibiogram and Klebocin typing
Author(s): Dr. Madhavilatha and Dr. Kamani Karthik
Abstract: Background: Hospital-acquired pneumonia (HAP) is a major cause of morbidity and mortality in hospitalized patients.
Klebsiella pneumoniae is a significant pathogen involved in HAP, often exhibiting multidrug resistance. This study aims to examine the epidemiological and bacteriological profiles of HAP at Sambhram Institute of Medical Sciences and Research, with a special focus on
Klebsiella pneumoniae and its characterization through antibiogram and Klebocin typing.
Materials and Methods: A prospective, one-year study was conducted from April 2019 to March 2020, including 1000 patients admitted to various hospital departments. Patients diagnosed with HAP based on established clinical and radiological criteria were included. Data collected included demographics, underlying comorbidities, and clinical details. Microbiological analysis of sputum, blood, and bronchial samples was conducted, with Klebocin typing used for characterization of Klebsiella pneumoniae strains. Antibiotic susceptibility was determined using the Kirby-Bauer disc diffusion method.
Results: Of the 1000 patients, 253 (25.3%) developed HAP, with the highest incidence observed in patients aged over 60 years (14.1%). Males were more affected than females (17.5% vs. 7.8%). Mechanical ventilation was associated with a higher incidence of HAP (15.7% vs. 9.6%). Microbiological analysis revealed Klebsiella pneumoniae as the most common pathogen (50.8%), followed by Pseudomonas aeruginosa and Escherichia coli. Klebocin typing of K. pneumoniae identified type 211 as the most prevalent.
Conclusion: The findings emphasize the significant burden of HAP, particularly in elderly male patients and those requiring mechanical ventilation. The predominance of Klebsiella pneumoniae and the diversity of its strains highlight the importance of environmental contamination control in hospital settings. Antimicrobial resistance patterns, particularly the high rate of ESBL-producing K. pneumoniae, underscore the need for continuous surveillance and targeted infection control strategies.
DOI: 10.22271/27069567.2020.v2.i1a.604Pages: 149-151 | Views: 50 | Downloads: 17Download Full Article: Click Here
How to cite this article:
Dr. Madhavilatha, Dr. Kamani Karthik.
Epidemiological and bacteriological profile of hospital-acquired pneumonia with special reference to Klebsiella pneumoniae and its characterization by Antibiogram and Klebocin typing. Int J Adv Res Med 2020;2(1):149-151. DOI:
10.22271/27069567.2020.v2.i1a.604