Correlation between liver dysfunction and renal microvascular complications in type 2 diabetes mellitus: A clinical and biochemical analysis
Author(s): Sankar Reddy and V Suresh
Abstract: Background: Diabetes mellitus is a long-term condition that arises when the body either fails to produce sufficient insulin or is unable to utilize it effectively. Compared to non-diabetic individuals, those with Type 2 Diabetes Mellitus (T2DM) face a significantly higher risk of cardiovascular complications and mortality, with cardiovascular disease being more prevalent in this population. This elevated risk is largely attributed to common risk factors such as hypertension, dyslipidaemia, and obesity. However, the increased incidence of cardiovascular disease in T2DM patients cannot be entirely explained by these traditional risk factors alone, suggesting the involvement of additional non-traditional contributors.
Methods: 80 T2DM patients underwent liver function tests (SGOT, SGPT, ALP, GGT), ultrasonography (NAFLD), and urine microalbumin analysis. Correlations with BMI, disease duration, and HbA1c were statistically analyzed. Statistical analysis in this study was conducted using the Student’s t-test (p<0.0001) and Pearson’s correlation coefficient (p<0.05).
Results: Liver enzymes, including SGOT, SGPT, and ALP, demonstrated a strong positive correlation with disease duration, HbA1c levels, liver echotexture changes, age, and BMI (p<0.05). 46.3% had elevated SGPT, 38.8% SGOT, 35% ALP, 15% GGT. NAFLD was present in 44%, and 31% had microalbuminuria, significantly correlating with BMI, HbA1c, and disease duration. Furthermore, a statistically significant association (p<0.0001) was observed between renal impairment and liver dysfunction in diabetic patients.
Discussion: In conclusion, our findings indicate that the pathophysiological mechanisms of T2DM contribute to increased liver enzyme levels, particularly SGOT, SGPT, and ALP, alongside hepatic echotexture alterations identified via ultrasonography. Microalbuminuria serves as a valuable marker for early nephropathy detection. Regular monitoring of liver enzymes through biochemical analysis and ultrasonographic screening in T2DM patients may facilitate timely intervention, potentially preventing disease progression and associated complications.
DOI: 10.22271/27069567.2020.v2.i1a.602Pages: 143-148 | Views: 52 | Downloads: 20Download Full Article: Click Here
How to cite this article:
Sankar Reddy, V Suresh.
Correlation between liver dysfunction and renal microvascular complications in type 2 diabetes mellitus: A clinical and biochemical analysis. Int J Adv Res Med 2020;2(1):143-148. DOI:
10.22271/27069567.2020.v2.i1a.602