Dr. Sripada Venkata Subhramanyam
Prediabetes is well-known to be a significant risk factor for type 2diabetes as well as heart disease and other chronic conditions. The pattern of multi-system involvement in prediabetes is similar to that of diabetic neuropathy. The purpose of this study was to determine the trend in fasting lipids in obese prediabetics who were obese at baseline.
Objective of the study: To study the serum lipid profile in prediabetic patients who are obese.
Materials and Methods: This study is a prospective case control study including 100 cases and 100 controls admitted to Shadan Institute of Medical Sciences, Hyderabad over a period of 18 months meeting the selection criteria. The relevant data was collected and the variables were analyzed using t test and chi square tests.
Results: The study evaluated 100 cases and 100 controls meeting the selection criteria. The mean age among the control group was 43 years, and it was 47.27 years in the case/study group. The body mass index (BMI) had a mean value of 29.4kg/m2 in the control group and averaged 28.09kg/m2 in the case group. The fasting blood sugar averaged 93 in the control group and had a mean value of 111.68 in the case group. The p value was <0.001 and was significant. The HbA1c used for defining patients of interest had a mean of 5.26 in the control group as against 6.06 among the case group, p value being significant at <0.001.Among 100 controls, 58 were females and 42 were males. In comparison, there were 46 females and 54 males in the case group. There were 44 subjects below the age of 45(inclusive) and 56 subjects who were above 45 years among the cases while the control group had 60 individuals who were more than 45 years of age and 40 individuals aged 45 years or less. Analysis did not show any statistically significant elevation in lipid parameters as far as age and gender delineation was concerned. It was also observed that HbA1c by itself was not an adequate tool for identifying dyslipidemia when compared to FBS.
Conclusion: This study concluded that serum lipid parameters are significantly elevated in prediabetic obese individuals barring HDL-c which is decreased. These prediabetic obese individuals because of their dyslipidemic status are at a higher risk for developing cardiovascular disease.
