GLUT-1 biomarker in predicting prognosis of VC and OSCC
Author(s): Dr. Sanjay Mishra MD and Dr. Shaikh Ifterkhar
Introduction: GLUT-1 is an endogenous marker of hypoxia which has been identified in diverse human tumors and there is evidence that GLUT-1 is associated with tumor aggressiveness in head and neck squamous cell carcinoma.
Aim: Evaluation and comparison of GLUT-1 expression in verrucous carcinoma & various grades of squamous cell carcinoma.
Objective: Our study aims to find the correlation of GLUT-1expression with the clinical and histopathological features of various lesions included in the study which are verrucous carcinoma and various grades of squamous cell carcinoma. It also aims at evaluating the aggressiveness of each individual lesion.
Materials & Method: Study group - Histopathologically diagnosed 10 verrucous carcinoma (VC) cases, 30 oral squamous cell carcinoma (OSCC) cases, 10 each of well differentiated, moderately differentiated and poorly differentiated were selected. Only primary carcinoma cases were considered. For control group- 10 biopsy specimen of normal oral mucosa that are taken during minor oral surgical procedures with patient consent. Immunohistochemisrty method was employed to evaluate the GLUT-1 expression in the various tissue sections.
Results: GLUT-1expression is increased VC and OSCC in comparison to normal mucosa. Its expression in various OSCC cases is correlated with the aggressiveness, local metastasis.
Conclusion: A better prognosis can be obtained by modifying treatment planning in accordance with the requirements of each lesion. Immunoexpression of GLUT-1 of tumour cells (VC & OSCC) can act as an adjunct in predicting the aggressiveness of each lesion.