Correlation of Oxidative Stress Markers, Antioxidants, Vegf and Apoa-I in Patients of Type 2 Diabetes Mellitus without Retinopathy
Author(s): Deepak Basia, Amrita Kulhria and Ravi Tandon
Abstract:Aims & Objectives: To measure the serum level of oxidative stress markers and level of antioxidants, an serum levels of VEGF & ApoA-I in patients of type 2 diabetes without retinopathy and its comparison with the healthy normotensive, non-diabetic controls and find the correlation between them. Results: Present study demonstrated enhanced level of the oxidants (MDA & Protein carbonyl) and a decreased levels of the antioxidants superoxide dismutase (SOD) in the cases i.e. type 2 diabetics without retinopathy whereas the controls showed the lower levels of the oxidants and the higher levels of the antioxidants. VEGF measured was significantly higher in the cases i.e. type 2 diabetics without retinopathy as compared to the healthy subjects. ApoA-I estimation in the diabetic patients was slightly lower as compared to the healthy controls. The difference between both the groups was not statistically significant (P= 0.096). Conclusion: Antioxidant supplementations and statins may have clinical usefulness in the treatment of this complex disorder and in preventing complications and progression, but the final verdict and consensus can only be obtained after well controlled large randomized studies.
Deepak Basia, Amrita Kulhria, Ravi Tandon. Correlation of Oxidative Stress Markers, Antioxidants, Vegf and Apoa-I in Patients of Type 2 Diabetes Mellitus without Retinopathy. Int J Adv Res Med 2019;1(1):37-41. DOI: 10.22271/27069567.2019.v1.i1a.323